• NEUROAXONAL DYSTROPHY DISEASE ( NAD )   

 

INTRODUCTION :  Mode of Inheritance is being studied but it has been

determined that it is a progressive disorder where brain and spinal cord

swelling occurs and deterioration continues. Nerve impulses become

abnormal and rear quarter coordination progress to general lack of all

control of movement. The puppy shows signs of pain in later stages.

It is believe to be autosomal recessive. ( This is the same type of inheritance as Progressive Retinal Atrophy PRA ).In order to produce offspring with this disease BOTH parents must carry the gene.

Clinical signs are awkward, clumsy, high stepping puppies Poor coordination, head tremors and in very young puppies it has been observed to be progressive and often by 19 weeks the puppy has to be euthanized on humane grounds. Older puppies continue to deteriorate, have difficulty in swallowing and pneumonia ensues. The brain and spinal cord atrophy ( shrink ).

To read formal abstract descriptions of the disease you may go to :

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• LINK : Neuroaxonal dystrophy in a litter of papillon pups.

• LINK : Neuroaxonal dystrophy in dogs: case report in 2 litters of Papillon puppies

• LINK : What is neuroaxonal dystrophy ?

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This information has been obtained through the above literature study .

There are reports of multiple puppy deaths made by some USA breeders.

The above information is furnished to the PCA membership by the Genetic Committee

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To read formal research studies that identified the genetic mutation for NAD,

you may go to :

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• LINK : Identification of the PLA2G6 c.1579G>A Missense Mutation in Papillon Dog

                  Neuroaxonal Dystrophy Using Whole Exome Sequencing Analysis

• LINK :  Initial survey of PLA2G6 missense variant causing neuroaxonal dystrophy in Papillon dogs

                  in North America and Europe 

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